2024
Alvarado Obando M, Rey-Varela D, Cava F, Dörr T. Genetic interaction mapping reveals functional relationships between peptidoglycan endopeptidases and carboxypeptidases. PLoS Genet. 2024 Pubmed
Gilmore MC, Yadav AK, Espaillat A, Gust AA, Williams MA, Brown PJB, Cava F. A peptidoglycan N-deacetylase specific for anhydroMurNAc chain termini in Agrobacterium tumefaciens. J Biol Chem. 2024 Pubmed
Espaillat A, Alvarez L, Torrens G, Ter Beek J, Miguel-Ruano V, Irazoki O, Gago F, Hermoso JA, Berntsson RP, Cava F. A distinctive family of L,D-transpeptidases catalyzing L-Ala-mDAP crosslinks in Alpha- and Betaproteobacteria. Nat Commun. 2024 Pubmed
Simpson BW, Gilmore MC, McLean AB, Cava F, Trent MS. Escherichia coli CadB is capable of promiscuously transporting muropeptides and contributing to peptidoglycan recycling. J Bacteriol. 2024 Pubmed
2023
Irazoki O, Ter Beek J, Alvarez L, Mateus A, Colin R, Typas A, Savitski MM, Sourjik V, Berntsson RP, Cava F. D-amino acids signal a stress-dependent run-away response in Vibrio cholerae. Nat Microbiol. 2023 Pubmed
Simpson BW, Gilmore MC, McLean AB, Cava F, Trent MS. Escherichia coli utilizes multiple peptidoglycan recycling permeases with distinct strategies of recycling. Proc Natl Acad Sci U S A. 2023 Pubmed
Midonet C, Bisset S, Shlosman I, Cava F, Rudner DZ, Bernhardt TG. MacP bypass variants of Streptococcus pneumoniae PBP2a suggest a conserved mechanism for the activation of bifunctional cell wall synthases. mBio. 2023 Pubmed
Boamah D, Gilmore MC, Bourget S, Ghosh A, Hossain MJ, Vogel JP, Cava F, O’Connor TJ. Peptidoglycan deacetylation controls type IV secretion and the intracellular survival of the bacterial pathogen Legionella pneumophila. Proc Natl Acad Sci U S A. 2023 Pubmed
Aurass P, Kim S, Pinedo V, Cava F, Isberg RR. Identification of Genes Required for Long-Term Survival of Legionella pneumophila in Water. mSphere. 2023 Pubmed
Zeden MS, Gallagher LA, Bueno E, Nolan AC, Ahn J, Shinde D, Razvi F, Sladek M, Burke Ó, O’Neill E, Fey PD, Cava F, Thomas VC, O’Gara JP. Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics. PLoS Pathog. 2023 Pubmed
Figueroa-Cuilan WM, Irazoki O, Feeley M, Smith E, Nguyen T, Cava F, Goley ED. Quantitative analysis of morphogenesis and growth dynamics in an obligate intracellular bacterium. Mol Biol Cell. 2023 Pubmed
Gómez-Arrebola C, Hernandez SB, Culp EJ, Wright GD, Solano C, Cava F, Lasa I. Staphylococcus aureus susceptibility to complestatin and corbomycin depends on the VraSR two-component system. Microbiol Spectr. 2023 Pubmed
Byström JW, Vikström L, Rosendal E, Gröning R, Gwon YD, Nilsson E, Sharma A, Espaillat A, Hanke L, McInerney G, Puhar A, Cava F, Karlsson Hedestam GB, Thunberg T, Monsen T, Elgh F, Evander M, Johansson AF, Överby AK, Ahlm C, Normark J, Forsell MN. At-home sampling to meet geographical challenges for serological assessment of SARS- CoV-2 exposure in a rural region of northern Sweden between March 1 and May 18, 2021, a retrospective cohort study. Eurosurveillance 2022 Pubmed
Aurass P, Kim S, Pinedo V, Cava F, Isberg RR. Identification of Genes Required for Long-Term Survival of Legionella pneumophila in Water. mSphere 2023 Pubmed
Daitch AK, Orsburn BC, Chen Z, Alvarez L, Eberhard CD, Sundararajan K, Zeinert R, Kreitler DF, Jakoncic J, Chien P, Cava F, Gabelli SB, Goley ED. EstG is a novel esterase required for cell envelope integrity in Caulobacter. Curr Biol. 2023 Pubmed
Sit B, Srisuknimit V, Bueno E, Zingl FG, Hullahalli K, Cava F, Waldor MK. Undecaprenyl phosphate translocases confer conditional microbial fitness. Nature. 2023 Pubmed
2022
Gilmore MC, Cava F. Peptidoglycan recycling mediated by an ABC transporter in the plant pathogen Agrobacterium tumefaciens. Nature Communications. 2022 Pubmed
Chan H, Taib N, Gilmore M, Mohamed A, Hanna K, Luhur J, Nguyen H, Hafiz E, Cava F, Gribaldo S, Rudner D, Rodrigues C. Genetic screens identify additional genes implicated in envelope remodeling during the engulfment stage of Bacillus subtilis sporulation. mBio. 2022 Pubmed
Bueno E, Pinedo V, Shinde DD, Mateus A, Typas A, Savitski MM, Thomas VC, Cava F. Transient glycolytic complexation of arsenate enhances resistance in the enteropathogen Vibrio cholerae. mBio. 2022 Pubmed
Figueroa-Cuilan W, Howell M, Richards C, Randich A, Yadav AK, Cava F, Brown PJB. Induction of AmpC-mediated β-lactam resistance requires a single lytic transglycosylase in Agrobacterium tumefaciens. Applied and Environmental Microbiology. 2022 Pubmed
Nyongesa S, Weber PH, Bernet E, Pulido F, Nieves C, Nieckarz M, Delaby M, Viehboeck T, Krause N, Rivera-Millot A, Nakamura A, Vischer NOE, van Nieuwenhze M, Brun YV, Cava F, Bulgheresi S, Veyrier FJ. Evolution of longitudinal division in multicellular bacteria of the Neisseriaceae family. Nature Communications. 2022 Pubmed
Mena-Bueno S, Poveda-Urkixo I, Irazoki O, Palacios L, Cava F, Zabalza-Baranguá A, Grilló MJ. Brucella melitensis Wzm/Wzt system: Changes in the bacterial envelope lead to improved Rev1? wzm vaccine properties. Frontiers in Microbiology. 2022 Pubmed
Giacomucci S, Alvarez L, Rodrigues CDA, Cava F, Paradis-Bleau C. Hydroxyl Radical Overproduction in the Envelope: an Achilles’ Heel in Peptidoglycan Synthesis. Microbiol Spectr. 2022 Pubmed
Hernández SB, Castanheira S, Pucciarelli MG, Cestero JJ, Rico-Pérez G, Paradela A, Ayala JA, Velázquez S, San-Félix A, Cava F, García-Del Portillo F. Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling. PLoS Pathog. 2022 Pubmed
Weaver AI, Alvarez L, Rosch KM, Ahmed A, Wang GS, van Nieuwenhze MS, Cava F, Dörr T. Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products. Elife. 2022 Pubmed
Delerue T, Anantharaman V, Gilmore MC, Popham DL, Cava F, Aravind L, Ramamurthi KS. Bacterial developmental checkpoint that directly monitors cell surface morphogenesis. Dev Cell. 2022 Pubmed
2021
Dai Y, Pinedo V, Tang AY, Cava F, Geisinger E. A New Class of Cell Wall-Recycling l,d-Carboxypeptidase Determines β-Lactam Susceptibility and Morphogenesis in Acinetobacter baumannii. mBio. 2021 Pubmed
Simpson BW, Nieckarz M, Pinedo V, McLean AB, Cava F, Trent MS. Acinetobacter baumannii Can Survive with an Outer Membrane Lacking Lipooligosaccharide Due to Structural Support from Elongasome Peptidoglycan Synthesis. mBio. 2021 Pubmed
Alvarez L, Hernandez SB, Cava F. Cell Wall Biology of Vibrio cholerae. Annu Rev Microbiol. 2021 Pubmed
Le NH, Pinedo V, Lopez J, Cava F, Feldman MF. Killing of Gram-negative and Gram-positive bacteria by a bifunctional cell wall-targeting T6SS effector. Proc Natl Acad Sci U S A. 2021 Pubmed
Williams MA, Aliashkevich A, Krol E, Kuru E, Bouchier JM, Rittichier J, Brun YV, VanNieuwenhze MS, Becker A, Cava F, Brown PJB. Unipolar Peptidoglycan Synthesis in the Rhizobiales Requires an Essential Class A Penicillin-Binding Protein. mBio. 2021 Pubmed
Campbell C, Fingleton C, Zeden MS, Bueno E, Gallagher LA, Shinde D, Ahn J, Olson HM, Fillmore TL, Adkins JN, Razvi F, Bayles KW, Fey PD, Thomas VC, Cava F, Clair GC, O’Gara JP. Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics. mBio. 2021 Pubmed
Aliashkevich A, Cava F. LD-transpeptidases: the great unknown among the peptidoglycan cross-linkers. FEBS J. 2021 Pubmed
Aliashkevich A, Howell M, Brown PJB, Cava F. d-canavanine affects peptidoglycan structure, morphogenesis and fitness in Rhizobiales. Environ Microbiol. 2021. Pubmed
Murphy S, Murtha A, Zhao Z, Alvarez L, Diebold P, Shin JH, VanNieuwenhze M, Cava F, Doerr T. Class A Penicillin-Binding Protein-mediated cell wall synthesis promotes structural integrity during peptidoglycan endopeptidase insufficiency. mBio 2021 Pubmed
Wang J, Alvarez L, Bulgheresi S, Cava F, den Blaauwen T. PBP4 Is Likely Involved in Cell Division of the Longitudinally Dividing Bacterium Candidatus Thiosymbion Oneisti. Antibiotics (Basel). 2021 Pubmed
del Peso Santos T, Alvarez L, Sit B, Irazoki O, Blake J, Warner BR, Warr AR, Bala A, Benes V, Waldor MK, Fredrick K , Cava F. BipA exerts temperature-dependent control of biofilm-associated colony morphology in Vibrio cholerae. eLife 2021 Pubmed
Espaillat A, Carrasco-López C, Bernardo-Garcia N, Rojas-Altuve A, Klett J, Morreale A, Hermoso JA, Cava F. Binding of non-canonical peptidoglycan controls Vibrio cholerae broad spectrum racemase activity. 2021 Computational and Structural Biotechnology Journal Pubmed
Gilmore MC, Ritzl-Rinkenberger B, Cava F. An updated toolkit for exploring bacterial cell wall structure and dynamics. F1000 Faculty reviews. 2021 Pubmed
Hernández SB, Cava F. New approaches and techniques for bacterial cell wall analysis. Current Opinion in Microbiology. 2021 Pubmed
2020
Espinosa E, Daniel S, Hernández SB, Goudin A, Cava F, Barre FX, Galli E. L-arabinose induces the formation of viable non-proliferating spheroplasts in Vibrio cholerae. Appl Environ Microbiol. 2020 Dec 18:AEM.02305-20. Pubmed
Wylensek D, Hitch TCA, Riedel T, Afrizal A, Kumar N, Wortmann E, Liu T, Devendran S, Lesker TR, Hernández SB, Heine V, Buhl EM, M D’Agostino P, Cumbo F, Fischöder T, Wyschkon M, Looft T, Parreira VR, Abt B, Doden HL, Ly L, Alves JMP, Reichlin M, Flisikowski K, Suarez LN, Neumann AP, Suen G, de Wouters T, Rohn S, Lagkouvardos I, Allen-Vercoe E, Spröer C, Bunk B, Taverne-Thiele AJ, Giesbers M, Wells JM, Neuhaus K, Schnieke A, Cava F, Segata N, Elling L, Strowig T, Ridlon JM, Gulder TAM, Overmann J, Clavel T. A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity. Nature Communications. 2020 Dec 15;11(1):6389. Pubmed
Rivera SL, Espaillat A, Aditham AK, Shieh P, Muriel-Mundo C, Kim J, Cava F, Siegrist MS. Bacterial Peptidoglycan Stapling with Functionalized D-Amino Acids. Cell Chemical Biology. 2020 Nov 20:S2451-9456(20)30435-9. Pubmed
Alvarez L, Cordier B, van Teeffelen S, Cava F. (2020). Analysis of Gram-negative Bacteria Peptidoglycan by Ultra-performance Liquid Chromatography. Bio-protocol 10(19): e3780. DOI: 10.21769/BioProtoc.3780.
Isnard C, Hernandez SB, Guérin F, Joalland F, Goux D, Gravey F, Auzou M, Enot D, Meignen P, Giard JC, Cava F, Cattoir V. Unexpected cell wall alteration-mediated bactericidal activity of the antifungal caspofungin against vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother. 2020 Aug 10:AAC.01261-20. Pubmed
Bueno E, Sit B, Waldor MK, Cava F. Genetic dissection of the fermentative and respiratory contributions supporting Vibrio cholerae hypoxic growth. Journal Bacteriology. 2020 Jul 6:JB.00243-20. Pubmed
Le NH, Peters K, Espaillat A, Sheldon JR, Gray J, Di Venanzio G, Lopez J, Djahanschiri B, Mueller EA, Hennon SW, Levin PA, Ebersberger I, Skaar EP, Cava F, Vollmer W, Feldman MF. Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare. Science Advances 2020 Jul 22;6(30):eabb5614. Pubmed
Rosendal E, Wigren J, Groening R, Yongdae K, Nilsson E, Sharma A, Espaillat A, Hanke L, Thunberg T, McInerney G, Puhar A, Cava F, Karlsson Hedestam GB, Monsen T, Elgh F, Blomkvist B, Marklund I, Ahlm C, Evander M, Normark J, Johansson A, Overby AK, Forsell M. Detection of asymptomatic SARS-CoV-2 exposed individuals by a sensitive S-based ELISA. medRxiv. 2020 Jun 4:2020.06.02.20120477. Pubmed
Bueno E, Pinedo V, Cava F. Adaptation of Vibrio cholerae to Hypoxic Environments. Front Microbiol. 2020 Apr 29;11:739. doi: 10.3389/fmicb.2020.00739. eCollection 2020. Pubmed
Shin JH, Sulpizio AG, Kelley A, Alvarez L, Murphy SG, Fan L, Cava F, Mao Y, Saper MA, Dörr T. Structural basis of peptidoglycan endopeptidase regulation. Proc Natl Acad Sci USA. 2020 May 26;117(21):11692-11702. Pubmed
Hernández SB, Dörr T, Waldor MK, Cava F. Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides. (2020) Cell Rep. 2020 Apr 28;31(4):107578. Pubmed
Amon JD, Yadav AK, Ramirez-Guadiana FH, Meeske AJ, Cava F, Rudner DZ. SwsB and SafA are required for CwlJ-dependent spore germination in Bacillus subtilis. (2019)J Bacteriol. pii: JB.00668-19. Pubmed
Woldemeskel SA, Daitch AK, Alvarez L, Panis G, Zeinert R, Gonzalez D, Smith E, Collier J, Chien P, Cava F, Viollier P, Goley ED. The conserved transcriptional regulator CdnL is required for metabolic homeostasis and morphogenesis in Caulobacter. (2020) PLOS Genetics Jan 21;16(1):e1008591. Pubmed
Vigouroux A, Cordier B, Aristov A, Alvarez L, Özbaykal G, Chaze T, Oldewurtel ER, Matondo M, Cava F, Bikard D, van Teeffelen S. Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects. (2020) Elife. 2020 Jan 6;9. pii: e51998. Pubmed
2019
Torrens G, Hernández SB, Ayala JA, Moya B, Juan C, Cava F, Oliver A. Regulation of AmpC-Driven β-Lactam Resistance in Pseudomonas aeruginosa: Different Pathways, Different Signaling. (2019) mSystems 4(6). pii: e00524-19. Pubmed
Jõers A, Vind K, Hernández SB, Maruste R, Pereira M, Brauer A, Remm M, Cava F, Tenson T. Muropeptides Stimulate Growth Resumption from Stationary Phase in Escherichia coli. (2019) Sci Rep. 9(1):18043. Pubmed
Kuru E, Radkov A, Meng X, Egan A, Alvarez L, Dowson A, Booher G, Breukink E, Roper DI, Cava F, Vollmer W, Brun Y, VanNieuwenhze MS. Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis. (2019) ACS Chem Biol. 14(12):2745-2756. Pubmed
Gallagher LA, Shears RK, Fingleton C, Alvarez L, Waters EM, Clarke J, Bricio-Moreno L, Campbell C, Yadav AK, Razvi F, O’Neill E, O’Neill AJ, Cava F, Fey PD, Kadioglu A, O’Gara JP. Impaired alanine transport or exposure to d-cycloserine increases the susceptibility of MRSA to β-lactam antibiotics. (2019) J Infect Dis. pii: jiz542. doi: 10.1093/infdis/jiz542. Pubmed
Chauhan D, Srivastava PA, Ritzl B, Yennamalli RM, Cava F, Priyadarshini R. Amino Acid-Dependent Alterations in Cell Wall and Cell Morphology of Deinococcus indicus DR1. (2019) Front Microbiol. 10:1449. Pubmed
Jacquier N, Yadav AK, Pillonel T, Viollier PH, Cava F, Greub G. A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum. (2019) MBio. 10(4). pii: e01128-19. Pubmed
Fleurie A, Zoued A, Alvarez L, Hines KM, Cava F, Xu L, Davis BM, Waldor MK. A Vibrio cholerae BolA-Like Protein Is Required for Proper Cell Shape and Cell Envelope Integrity. (2019) MBio. 10(4). pii: e00790-19. Pubmed
Bernardo-García N, Sánchez-Murcia PA, Espaillat A, Martínez-Caballero S, Cava F, Hermoso JA, Gago F. Cold-induced aldimine bond cleavage by Tris in Bacillus subtilis alanine racemase. (2019) Org Biomol Chem. 17(17):4350-4358. Pubmed
Hsu YP, Hall E, Booher G, Murphy B, Radkov AD, Yablonowski J, Mulcahey C, Alvarez L, Cava F, Brun YV, Kuru E, VanNieuwenhze MS. Fluorogenic D-amino acids enable real-time monitoring of peptidoglycan biosynthesis and high-throughput transpeptidation assays. (2019) Nat Chem. Apr;11(4):335-341. Pubmed
Irazoki O, Hernandez SB, Cava F. Peptidoglycan Muropeptides: Release, Perception, and Functions as Signaling Molecules. (2019) Front Microbiol. 10:500. doi: 10.3389/fmicb.2019.00500. Pubmed
Murphy SG, Alvarez L, Adams MC, Liu S, Chappie JS, Cava F, Dörr T. Endopeptidase Regulation as a Novel Function of the Zur-Dependent Zinc Starvation Response. (2019) mBio Feb 19;10(1). pii: e02620-18. doi: 10:e02620-18. Pubmed
Howell M, Aliashkevich A, Sundararajan K, Daniel JJ, Lariviere PJ, Goley ED, Cava F, Brown PJB. Agrobacterium tumefaciens divisome proteins regulate the transition from polar growth to cell division. (2019) Mol Microbiol. Jan 29. doi: 10.1111/mmi.14212. Pubmed
2018
Bueno E, Sit B, Waldor MK, Cava F. Anaerobic nitrate reduction divergently governs population expansion of the enteropathogen Vibrio cholerae. (2018) Nat Microbiol. 3(12):1346-1353. Pubmed
Yadav AK, Espaillat A, Cava F. Bacterial Strategies to Preserve Cell Wall Integrity Against Environmental Threats. (2018) Front Microbiol. 9:2064. Pubmed
Kouidmi I, Alvarez L, Collet JF, Cava F, Paradis-Bleau C. The Chaperone Activities of DsbG and Spy Restore Peptidoglycan Biosynthesis in the elyC Mutant by Preventing Envelope Protein Aggregation. (2018) J Bacteriol. 200(19). pii: e00245-18. Pubmed
Orrego AH, Lopez-Gallego F, Espaillat A, Cava F, Guisan JM, Rocha-Martin J. One‐step Synthesis of α‐Keto Acids from Racemic Amino Acids by A Versatile Immobilized Multienzyme Cell‐free System. (2018) ChemCatChem 10(14). doi
Aliashkevich A, Alvarez L, Cava F. New Insights Into the Mechanisms and Biological Roles of D-Amino Acids in Complex Eco-Systems. (2018) Front Microbiol. 9:683. Pubmed
Kumar K, Cava F. Principal coordinate analysis assisted chromatographic analysis of bacterial cell wall collection: A robust classification approach. (2018) Anal Biochem. 550:8-14. Pubmed
Alvarez L, Aliashkevich A, de Pedro MA, Cava F. Bacterial secretion of D-arginine controls environmental microbial biodiversity. (2018) ISME J. 12(2):438-450. Pubmed
Kumar K, Cava F. Integrating network analysis with chromatography: introducing a novel chemometry-chromatography based analytical procedure to classify the bacterial cell wall collection. (2018) Analytical Methods 10(10):1172-1180. doi
2017
Cava F. Divergent functional roles of D-amino acids secreted by Vibrio cholerae. (2017) Int Microbiol. 20(3):149-150. Pubmed
Cava F. Biology of Vibrio cholera. Editorial overview. (2017) Int Microbiol. 20(3):105. Pubmed
Castanheira S, Cestero JJ, Rico-Pérez G, García P, Cava F, Ayala JA, Pucciarelli MG, García-Del Portillo F. A Specialized Peptidoglycan Synthase Promotes Salmonella Cell Division inside Host Cells. (2017) MBio. 8(6). pii: e01685-17. Pubmed
Maciejewska B, Źrubek K, Espaillat A, Wiśniewska M, Rembacz KP, Cava F, Dubin G, Drulis-Kawa Z. Modular endolysin of Burkholderia AP3 phage has the largest lysozyme-like catalytic subunit discovered to date and no catalytic aspartate residue. (2017) Sci Rep. 7(1):14501. Pubmed
Kumar K, Espaillat A, Cava F. PG-Metrics: A chemometric-based approach for classifying bacterial peptidoglycan data sets and uncovering their subjacent chemical variability. (2017) PLoS One. 12(10):e0186197. Pubmed
van Teeseling MCF, de Pedro MA, Cava F. Determinants of Bacterial Morphology: From Fundamentals to Possibilities for Antimicrobial Targeting. (2017) Front Microbiol. 8:1264. Pubmed
Howell M, Aliashkevich A, Salisbury AK, Cava F, Bowman GR, Brown PJB. Absence of the Polar Organizing Protein PopZ Results in Reduced and Asymmetric Cell Division in Agrobacterium tumefaciens. (2017) J Bacteriol. 199(17). pii: e00101-17. Pubmed
Kumar K, Cava F. Constraint randomised non-negative factor analysis (CRNNFA): an alternate chemometrics approach for analysing the biochemical data sets. (2017) Analyst. 142(11):1916-1928. Pubmed
Moreno-Guzman M, Garcia-Carmona L, Molinero-Fernandez A, Cava F, Lopez Gil MA, Escarpa A. Bi-enzymatic biosensor for on-site, fast and reliable electrochemical detection of relevant D-amino acids in bacterial samples. (2017) Sensors and actuators. B, Chemical 242, 95-101. doi
Terceti MS, Rivas AJ, Alvarez L, Noia M, Cava F, Osorio CR. rstB Regulates Expression of the Photobacterium damselae subsp. damselae Major Virulence Factors Damselysin, Phobalysin P and Phobalysin C. (2017) Front Microbiol. 8:582. Pubmed
Vanderlinde EM, Strozen TG, Hernández SB, Cava F, Howard SP. Alterations in Peptidoglycan Cross-Linking Suppress the Secretin Assembly Defect Caused by Mutation of GspA in the Type II Secretion System. (2017) J Bacteriol. 199(8). pii: e00617-16. Pubmed
Kudrin P, Varik V, Oliveira SR, Beljantseva J, Del Peso Santos T, Dzhygyr I, Rejman D, Cava F, Tenson T, Hauryliuk V. Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to β-Lactams. (2017) Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02173-16. Pubmed
Abraham NM, Liu L, Jutras BL, Yadav AK, Narasimhan S, Gopalakrishnan V, Ansari JM, Jefferson KK, Cava F, Jacobs-Wagner C, Fikrig E. Pathogen-mediated manipulation of arthropod microbiota to promote infection. (2017) Proc Natl Acad Sci U S A. 114(5):E781-E790. Pubmed
Maciejewska B, Roszniowski B, Espaillat A, Kęsik-Szeloch A, Majkowska-Skrobek G, Kropinski AM, Briers Y, Cava F, Lavigne R, Drulis-Kawa Z. Klebsiella phages representing a novel clade of viruses with an unknown DNA modification and biotechnologically interesting enzymes. (2017) Appl Microbiol Biotechnol. 101(2):673-684. Pubmed
2016
Bernardo-Garcia N, Sanchez-Murcia P, Gago F, Cava F, Hermoso JA. Structural Bioinformatics in Broad-Spectrum Racemases: a new path in anti-microbial research. (2016) Current Organic Chemistry 20(11), 1222-1231. doi
Felgner S, Frahm M, Kocijancic D, Rohde M, Eckweiler D, Bielecka A, Bueno E, Cava F, Abraham WR, Curtiss R 3rd, Häussler S, Erhardt M, Weiss S. aroA-Deficient Salmonella enterica Serovar Typhimurium Is More Than a Metabolically Attenuated Mutant. (2016) MBio. 7(5). pii: e01220-16. Pubmed
Espaillat A, Forsmo O, El Biari K, Björk R, Lemaitre B, Trygg J, Cañada FJ, de Pedro MA, Cava F. Chemometric Analysis of Bacterial Peptidoglycan Reveals Atypical Modifications That Empower the Cell Wall against Predatory Enzymes and Fly Innate Immunity. (2016 ) J Am Chem Soc. 138(29):9193-204. Pubmed
Alvarez L, Hernandez SB, de Pedro MA, Cava F. Ultra-Sensitive, High-Resolution Liquid Chromatography Methods for the High-Throughput Quantitative Analysis of Bacterial Cell Wall Chemistry and Structure. (2016) Methods Mol Biol. 1440:11-27. Pubmed
Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezée-Durant E, Arnoux P. Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus. (2016) Science. 352(6289):1105-9. Pubmed
Cuenca M, Pfister SP, Buschor S, Bayramova F, Hernandez SB, Cava F, Kuru E, Van Nieuwenhze MS, Brun YV, Coelho FM, Hapfelmeier S. D-Alanine-Controlled Transient Intestinal Mono-Colonization with Non-Laboratory-Adapted Commensal E. coli Strain HS. (2016) PLoS One. 11(3):e0151872. Pubmed
Dörr T, Alvarez L, Delgado F, Davis BM, Cava F, Waldor MK. A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance. (2016) Proc Natl Acad Sci U S A. 113(2):404-9. Pubmed
Hernández SB, Cava F. Environmental roles of microbial amino acid racemases. (2016) Environ Microbiol. 18(6):1673-85. Pubmed
2015
Desmarais SM, Tropini C, Miguel A, Cava F, Monds RD, de Pedro MA, Huang KC. High-throughput, Highly Sensitive Analyses of Bacterial Morphogenesis Using Ultra Performance Liquid Chromatography. (2015) J Biol Chem. 290(52):31090-100. Pubmed
Le Roux F, Wegner KM, Baker-Austin C, Vezzulli L, Osorio CR, Amaro C, Ritchie JM, Defoirdt T, Destoumieux-Garzón D, Blokesch M, Mazel D, Jacq A, Cava F, Gram L, Wendling CC, Strauch E, Kirschner A, Huehn S. The emergence of Vibrio pathogens in Europe: ecology, evolution, and pathogenesis (Paris, 11-12th March 2015). (2015) Front Microbiol. 6:830. Pubmed
de Pedro MA, Cava F. Structural constraints and dynamics of bacterial cell wall architecture. (2015) Front Microbiol. 6:449. Pubmed
van Teeseling MC, Mesman RJ, Kuru E, Espaillat A, Cava F, Brun YV, VanNieuwenhze MS, Kartal B, van Niftrik L. Anammox Planctomycetes have a peptidoglycan cell wall. (2015) Nat Commun. 6:6878. Pubmed
Siegrist MS, Aditham AK, Espaillat A, Cameron TA, Whiteside SA, Cava F, Portnoy DA, Bertozzi CR. Host actin polymerization tunes the cell division cycle of an intracellular pathogen. (2015) Cell Rep. 11(4):499-507. Pubmed
Möll A, Dörr T, Alvarez L, Davis BM, Cava F, Waldor MK. A D, D-carboxypeptidase is required for Vibrio cholerae halotolerance. (2015) Environ Microbiol. 17(2):527-40. Pubmed
Hernández SB, Cava F, Pucciarelli MG, García-Del Portillo F, de Pedro MA, Casadesús J. Bile-induced peptidoglycan remodelling in Salmonella enterica. (2015) Environ Microbiol. 17(4):1081-9. Pubmed
2014
Möll A, Dörr T, Alvarez L, Chao MC, Davis BM, Cava F, Waldor MK. Cell separation in Vibrio cholerae is mediated by a single amidase whose action is modulated by two nonredundant activators. (2014) J Bacteriol. 196(22):3937-48. Pubmed
Dörr T, Lam H, Alvarez L, Cava F, Davis BM, Waldor MK. A novel peptidoglycan binding protein crucial for PBP1A-mediated cell wall biogenesis in Vibrio cholerae. (2014) PLoS Genet. 10(6):e1004433. Pubmed
Alvarez L, Espaillat A, Hermoso JA, de Pedro MA, Cava F. Peptidoglycan remodeling by the coordinated action of multispecific enzymes. (2014) Microb Drug Resist. 20(3):190-8. Pubmed
Dörr T, Möll A, Chao MC, Cava F, Lam H, Davis BM, Waldor MK. Differential requirement for PBP1a and PBP1b in in vivo and in vitro fitness of Vibrio cholerae. (2014) Infect Immun. 82(5):2115-24. Pubmed
Cava F, de Pedro MA. Peptidoglycan plasticity in bacteria: emerging variability of the murein sacculus and their associated biological functions. (2014) Curr Opin Microbiol. 18:46-53. Pubmed
Desmarais SM, Cava F, de Pedro MA, Huang KC. Isolation and preparation of bacterial cell walls for compositional analysis by ultra performance liquid chromatography. (2014) J Vis Exp. (83):e51183. Pubmed
Espaillat A, Carrasco-López C, Bernardo-García N, Pietrosemoli N, Otero LH, Álvarez L, de Pedro MA, Pazos F, Davis BM, Waldor MK, Hermoso JA, Cava F. Structural basis for the broad specificity of a new family of amino-acid racemases. (2014) Acta Crystallogr D Biol Crystallogr. 70(Pt 1):79-90. Pubmed
2013
Cava F, Kuru E, Brun YV, de Pedro MA. Modes of cell wall growth differentiation in rod-shaped bacteria. (2013) Curr Opin Microbiol. 16(6):731-7. Pubmed
Dörr T, Cava F, Lam H, Davis BM, Waldor MK. Substrate specificity of an elongation-specific peptidoglycan endopeptidase and its implications for cell wall architecture and growth of Vibrio cholerae. (2013) Mol Microbiol. 89(5):949-62. Pubmed.
Desmarais SM, De Pedro MA, Cava F, Huang KC. Peptidoglycan at its peaks: how chromatographic analyses can reveal bacterial cell wall structure and assembly. (2013) Mol Microbiol. 89(1):1-13. Pubmed
Siegrist MS, Whiteside S, Jewett JC, Aditham A, Cava F, Bertozzi CR. (D)-Amino acid chemical reporters reveal peptidoglycan dynamics of an intracellular pathogen. (2013) ACS Chem Biol. 8(3):500-5. Pubmed